Brand logo & Packshot - Nexmatch Forte™ 1.5 g / Nexmatch Forte™ 3 g.
Composition - Nexmatch Forte™ 1.5 g - Cefoperazone Sodium IP (Sterile) eq. to Anhydrous Cefoperazone 1 gm Sulbactam Sodium IP (Sterile) eq. to Sulbactam 0.5 gm.
Nexmatch Forte™ 3 g - Cefoperazone Sodium IP (Sterile) eq. to Anhydrous Cefoperazone 2 gm Sulbactam Sodium IP (Sterile) eq. to Sulbactam 1 gm.
Description - Cefoperazone is a third-generation cephalosporin antibiotic. Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis, and sulbactam acts as a beta-lactamase inhibitor, to increase the antibacterial activity of cefoperazone against beta-lactamase-producing organisms.
Indications & Usage - Indicated for the treatment of the following infections when caused by susceptible organisms: Respiratory tract infections (upper and lower); Urinary tract infections (upper and lower); Peritonitis, cholecystitis, cholangitis, and other intra-abdominal infections; Septicaemia; Meningitis; Skin and soft tissue infections; Bone and joint infections; Pelvic inflammatory disease, endometritis, gonorrhoea, and other infections of the genital tract.
Dosage & administration - In adults, Daily dosage recommendations for Sulbactam / Cefoperazone in adults are as follows:
Ratio
Sulbactam/ Cefoperazone (g)
Sulbactam activity (g)
Cefoperazone activity (g)
1:2
3.0-6.0
1.0-2.0
2.0-4.0
Doses should be administered every 12 hours in equally divided doses. In severe or refractory infections, the daily dosage of sulbactam/cefoperazone may be increased up to 8 g of the 1:1 ratio (i.e. 4 g of cefoperazone activity) or 12 g of the 1:2 ratio (i.e. 8 g of cefoperazone activity). Patients receiving the 1:1 ratio may require additional cefoperazone administered separately. Doses should be administered every 12 hours in equally divided doses. The recommended maximum daily dosage of sulbactam is 4 g. In febrile neutropenia, total daily dose can be administered twice or thrice a day in equally divided doses. In Paediatric patients, Daily dosage recommendations for Sulbactam / Cefoperazone in children are as follows:
Ratio
Sulbactam/ Cefoperazone (mg/kg/day)
Sulbactam activity (mg/kg/day)
Cefoperazone activity (mg/kg/day)
1:1
40-80
20-40
20-40
1:2
60-120
20-40
40-80
Doses should be administered every 6 to 12 hours in equally divided doses. In serious or refractory infections, these dosages may be increased up to 160 mg/kg/day or 240 mg/kg/day of the 1:2 ratio (160 mg/kg/day cefoperazone activity). Doses should be administered in two to four equally divided doses. Use in Neonates - For neonates in the first week of life, the drug should be given every 12 hours. The maximum daily dosage of sulbactam in paediatric patients should not exceed 80 mg/kg/day. If more than 80 mg/kg/day of cefoperazone activity is necessary, additional cefoperazone should be administered separately.
Storage Conditions - Store below 30°C. Protect from light & moisture. Do not freeze. Reconstituted solution is stable for 7 days at 2-8°C and for 24 hours at 8-25°C.
