Composition - Each vial contains Meropenem IP equivalent to anhydrous Meropenem 1000 mg, sterile Sulbactum sodium IP 500 mg is added as buffer.
Description - Meropenem is a broad-spectrum carbapenem antibiotic. The bactericidal activity of Meropenem results from the inhibition of cell wall synthesis. Meropenem readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding-protein (PBP) targets. Sulbactam is a β-lactamase inhibitor. This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics. Sulbactam in the Meropenem and Sulbactam for Injection formulation effectively extends the antibiotic spectrum of Meropenem to include many bacteria normally resistant.
Indications & Usage - Mepecon-SB is indicated for the treatment of the following infection when caused by susceptible isolates of the designated microorganisms: For the treatment of lower respiratory tract infection caused by gram negative bacteria in adults only.
Dosage & administration - Adults: The recommended dose of Mepecon SB is 1.5 gm (1 gm Meropenem + 500 mg sulbactam) given every 8 hourly. Mepecon SB should be administered by intravenous infusion over approximately 15 to 30 minutes & intravenous bolus injection over approximately 3-5 minutes. Adults with Renal Impairment: Dosage should be reduced in patients with creatinine clearance less than 51 mL/min.
Storage conditions - Store below 25°C protected from light & moisture. Do not allow to freeze.