Indications & Usage - For the treatment of Rheumatoid Arthritis, NHL, CLL
Dosage & administration -
Administer Only as an Intravenous Infusion.
Do not administer as an intravenous push or bolus.
The dose for NHL is 375 mg/m2.
The dose for CLL is 375 mg/m2 in the first cycle and 500 mg/m2 in cycles, in combination with FC, administered every 28 days.
The dose for RA in combination with methotrexate is two-1000 mg intravenous infusions separated by 2 weeks (one course) every 24 weeks or based on clinical evaluation, but not sooner than every 16 weeks. Methylprednisolone 100 mg intravenous or equivalent glucocorticoid is recommended 30 minutes prior to each infusion.
The dose for GPA and MPA in combination with glucocorticoids is 375 mg/m2 once weekly for 4 weeks.
