Prophylaxis of Organ Rejection in Renal Transplantation
Prophylaxis of Organ Rejection in Liver Transplantation
Dosage & administration - Dosage in Adult Kidney Transplant Patients
An initial everolimus dose of 0.75 mg orally twice daily (1.5 mg per day) is recommended for adult kidney transplant patients in combination with reduced dose cyclosporine, administered as soon as possible after transplantation.
Patients receiving Evercon may require dose adjustments based on everolimus blood concentrations achieved, tolerability, individual response, change in concomitant medications and the clinical situation. Optimally, dose adjustments should be based on trough concentrations obtained 4 or 5 days after a previous dosing change.
Oral prednisone should be initiated once oral medication is tolerated. Steroid doses may be further tapered on an individualized basis depending on the clinical status of patient and function of graft.
